ArtNr |
ELS-PKSM040902-100ug |
Hersteller |
Elabscience
|
Menge |
100ug |
Kategorie |
|
Typ |
Proteins |
Specific against |
Mouse |
Host |
HEK293 cells |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
AI528646,CD32,F630109E10Rik,Fcgr2,Fcgr2a,FcgRII,Fcr-2,Fcr-3,fcRII,Fc[g]RII,Ly-17,Ly-m20,LyM-1 |
Similar products |
CD32, Fcgr2, FcgRII, Fc[g]RII, Fcr-2, Fcr-3, Ly-17, Ly-m20, LyM-1, AI528646, F630109E10Rik, Fcgr2a, fcRII |
Lieferbar |
|
Synonym |
AI528646, CD32, F630109E10Rik, Fcgr2, Fcgr2a, FcgRII, Fcr-2, Fcr-3, fcRII, Fc[g]RII, Ly-17, Ly-m20, LyM-1 |
Storage |
according to manual |
Activity |
Measured by its binding ability in a functional ELISA.Immobilized mouse FCGR2B-His (CD32) at 10 ug/ml (100 ul/well) can bind biotinylated human IgG1, The EC50 of biotinylated human IgG1 is 0.13-0.29 ug/ml. |
Protein Construction |
A DNA sequence encoding the extracellular domain (Met 1-Arg 217) of mouse FCGR2B (NP_001070657.1) precursor was expressed with a polyhistidine tag at the C-terminus. |
Sequence |
Met 1-Arg 217 |
Fusion tag |
C-His |
Accession |
NP_001070657.1 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 98 % as determined by SDS-PAGE |
Endotoxin |
< 1.0 EU per ug of the protein as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
21.7 kDa |
AP Mol Mass |
35-40 kDa |
Formulation |
Lyophilized from sterile PBS, pH 7.4 |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
Receptors for Fc portion of IgG (Fcγ Rs) are members of the Ig superfamily, and are divided into three classes designated Fcγ RI (CD64), Fcγ RII (CD32), and Fcγ RIII (CD16). CD32 protein is a low affinity receptor for IgG that binds only IgG immune complexes and is expressed on a diverse range of cells such as monocytes, macrophages, neutrophils, eosinophils, platelets, and B cells. Human CD32 class is encoded by three closely related genes, and designated Fcγ RII A, B, and C which share 94-99% amino acid identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. CD32 is involved in a number of immune responses including antibody-dependent cell-mediated cytotoxicity, clearance of immune complexes, release of inflammatory mediators, and regulation of antibody production. |
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