ArtNr |
ELS-PKSM040390-10ug |
Hersteller |
Elabscience
|
Menge |
10ug |
Kategorie |
|
Typ |
Proteins |
Specific against |
Mouse |
Host |
HEK293 cells |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Thymic stromal lymphopoietin,Thymic stroma-derived lymphopoietin,Tslp,TSLP |
Similar products |
TSLP, Thymic stromal lymphopoietin, Tslp, Thymic stroma-derived lymphopoietin |
Lieferbar |
|
Synonym |
Thymic stromal lymphopoietin, Thymic stroma-derived lymphopoietin, Tslp, TSLP |
Storage |
according to manual |
Activity |
Measured by its ability to bind human IL7RA-his in functional ELISA. |
Protein Construction |
A DNA sequence encoding the mouse TSLP (Q9JIE6) (Met 1-Glu 140) was expressed, with a C-terminal polyhistidine tag. |
Sequence |
Met 1-Glu 140 |
Fusion tag |
C-His |
Accession |
Q9JIE6 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 90 % as determined by SDS-PAGE |
Endotoxin |
< 1.0 EU per ug of the protein as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
15.4 kDa |
AP Mol Mass |
22-27 kDa |
Formulation |
Lyophilized from sterile PBS, pH 7.4 |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs). Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, and is important in allergic inflammation. Subsequent studies have shown that TSLP promotes T helper type 2 (TH2) cell responses associated with immunity to some helminth parasites and the pathogenesis of many inflammatory diseases, including atopic dermatitis and asthma. TSLP can promote TH2 cytokine-associated inflammation by directly promoting the effector functions of CD4+ TH2 cells, basophils and other granulocyte populations while simultaneously limiting the expression of DC-derived proinflammatory cytokines and promoting regulatory T cell responses in peripheral tissues. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.