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Recombinant Human PD-1/PDCD1 Protein (mFc Tag)

ArtNr ELS-PKSH032864-10ug
Hersteller Elabscience
Menge 10 ug
Quantity options 10 ug 50 ug
Kategorie
Typ Proteins
Format Lyophilized Powder
Applikationen ELISA
Specific against Human (Homo sapiens)
Host HEK293 cells
Konjugat/Tag C-mFc
Purity > 95 % as determined by reducing SDS-PAGE.
Sequence Pro21-Gln167
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias CD279, Hsle1, PD-1, PDCD1, Programmed cell death protein 1, SLEB2, hPD-1
Similar products PD-1, PDCD1, CD279, SLEB2, hPD-1, Programmed cell death protein 1, Hsle1
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Category
Recombinant Proteins / Immune Checkpoint Proteins
Manufacturer - Conjugate / Tag
C-mFc
Shipping Temperature
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Calculated Molecular Weight
42.0 kDa
Observed Molecular Weight
60 kDa
Research Areas
Cell biology, Cancer, immunology
Background
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1; IL-4; IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition; coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance; and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule; PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation; cytokine production; and cytolytic function.
Abbreviation
PD-1; PDCD1
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Reconstitution
Please refer to the printed manual for detailed information.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Activity
Immobilized Anti-Human PD-1 mAb at 2μg/ml (100 μl/well) can bind Human PD-1-mFc. The ED50 of Human PD-1-mFc is 12.53 ng/ml.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 10 ug
Lieferbar: In stock
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