Hersteller |
Elabscience
|
Kategorie |
|
Typ |
Proteins |
Specific against |
Human |
Menge |
50ug |
Host |
Human Cells |
ArtNr |
ELS-PKSH032753-50ug |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Alias |
MHC Class I Polypeptide-Related Sequence A, MIC-A, MICA, PERB11.1 |
Synonym |
MHC Class I Polypeptide-Related Sequence A, MIC-A, MICA, PERB11.1 |
Storage |
according to manual |
Activity |
Immobilized Human MICA-Fc at 2ug/ml(100 ul/well) can bind Human NKG2DL2-His(Cat: PKSH032816). The ED50 of Human MICA-Fc is 2.29 ug/ml . |
Protein Construction |
Recombinant Human MHC Class I Polypeptide-Related Sequence A is produced by our Mammalian expression system and the target gene encoding Ala23-Glu308 is expressed with a Fc tag at the C-terminus. |
Sequence |
Ala23-Glu308 |
Fusion tag |
C-Fc |
Accession |
Q29983 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 95 % as determined by reducing SDS-PAGE. |
Endotoxin |
< 1.0 EU per ug as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
59.9 kDa |
AP Mol Mass |
88 kDa |
Formulation |
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
MHC class I polypeptide-related sequence A, also known as MIC-A, PERB11.1 and MICA, is a single-pass type I membrane protein which belongs to the MHC class I family of MIC subfamily. MICA contains one Ig-like C1-type domain and is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. MICA is the ligand for NK cell activating receptor KLRK1/NKG2D. MICA seems to have no role in antigen presentation. MICA leads to cell lysis by binding to KLRK1. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.