ArtNr |
ELS-PKSH032420-50ug |
Hersteller |
Elabscience
|
Menge |
50ug |
Kategorie |
|
Typ |
Proteins |
Specific against |
Human |
Host |
Human Cells |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A, CD16a Antigen, Fc-Gamma RIII-Alpha, Fc-Gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc Receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3,CD16,CD16A |
Similar products |
FCGR3A, CD16A, FCG3, FCGR3, IGFR3, FcR-10, CD16, Fc-gamma RIIIa, CD16a, FcRIII, FcRIIIa, Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A, CD16a Antigen, Fc-Gamma RIII-Alpha, Fc-Gamma RIII, IgG Fc Receptor III-2 |
Lieferbar |
|
Synonym |
Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A, CD16a Antigen, Fc-Gamma RIII-Alpha, Fc-Gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc Receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3, CD16, CD16A |
Storage |
according to manual |
Protein Construction |
Recombinant Human Fc gamma RIIIA is produced by our Mammalian expression system and the target gene encoding Gly17-Gln208(Val176Phe) is expressed with a 6His tag at the C-terminus. |
Sequence |
Gly17-Gln208(Val176Phe) |
Fusion tag |
C-6His |
Accession |
P08637 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 95 % as determined by reducing SDS-PAGE. |
Endotoxin |
< 1.0 EU per ug as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
22.7 kDa |
AP Mol Mass |
35-50 kDa |
Formulation |
Lyophilized from a 0.2 um filtered solution of PBS; pH7.4. |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
Receptors for the Fc region of immunoglobin G (FcgammaR) are divided into three classes and FcgammaRIII is a multifunctional; low/intermediate affinity receptor. In humans; FcgammaRIII is expressed as two distinct forms (FcgammaRIIIA and FcgammaRIIIB) that are encoded by two different but highly homologous genes in a cell type-specific manner. FcgammaRIIIB is a low-affinity; GPI-linked receptor expressed by neutrophils and eosinophils; whereas FcgammaRIIIA is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes; natural killer (NK) cells; monocytes; and macrophages. The FcgammaRIIIA receptor is involved in phagocytosis; secretion of enzymes; inflammatory mediators; antibody-dependent cellular cytotoxicity (ADCC); mast cell degranulation; and clearance of immune complexes. FcgammaRIIIA has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. Aberrant expression or mutations in this gene is implicated in susceptibility to recurrent viral infections; systemic lupus erythematosus; and alloimmune neonatal neutropenia. In humans; it is a 50 -70 kD type I transmembrane activating receptor. |
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