ArtNr |
ELS-PKSH032413-10ug |
Hersteller |
Elabscience
|
Menge |
10ug |
Kategorie |
|
Typ |
Proteins |
Specific against |
Human |
Host |
Human Cells |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, APT1, FAS1, TNFRSF6 and FAS |
Similar products |
APT1, FAS1, Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, TNFRSF6 and FAS |
Lieferbar |
|
Synonym |
Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, APT1, FAS1, TNFRSF6 and FAS |
Storage |
< -20CC |
Protein Construction |
Recombinant Human Fibroblast-associated is produced by our Mammalian expression system and the target gene encoding Gln26-Asn173 is expressed with a Fc tag at the C-terminus. |
Sequence |
Gln26-Asn173 |
Fusion tag |
C-Fc |
Accession |
P25445 |
Shipping |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20CC. |
Purity |
> 95 % as determined by reducing SDS-PAGE. |
Endotoxin |
< 1.0 EU per ug as determined by the LAL method. |
Stability and Storage |
Store at < -20CC, stable for 6 months. Please minimize freeze-thaw cycles. |
Mol Mass |
44.6 kDa |
AP Mol Mass |
60 kDa |
Formulation |
Supplied as a 0.2 um filtered solution of PBS, pH 7.4. |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
FAS(TNFRSF6) is a receptor and contains three TNFR-Cys repeats and one death domain. It has been shown that FAS is involved in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. FADD (adapter molecule) recruits caspase-8 to the activated receptor, the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may play a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.