ArtNr |
ELS-PKSH031849-100ug |
Hersteller |
Elabscience
|
Menge |
100ug |
Kategorie |
|
Typ |
Proteins |
Specific against |
Human |
Host |
HEK293 cells |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
CD121A,D2S1473,IL-1 RI,IL-1R-alpha,IL-1R1,IL1R,IL1RA,P80,Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1, IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha |
Similar products |
IL1R, IL1RA, Interleukin-1 receptor type 1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, Interleukin-1 receptor type 1, IL-1R1, CD121A, D2S1473, IL-1R-alpha, P80, IL-1 RI, IL-1R-1, IL-1RT-1, IL-1RT1 |
Lieferbar |
|
Synonym |
CD121A, D2S1473, IL-1 RI, IL-1R-alpha, IL-1R1, IL1R, IL1RA, P80, Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1, IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha |
Storage |
according to manual |
Activity |
1. Measured by its binding ability in a functional ELISA. Immobilized human IL1-beta at 20 ug/ml (100 ul/well) can bind human IL1R1 Fc chimera with a linear ranger of 6.4-160 ng/ml.2. Measured by its binding ability in a functional ELISA.3. Immobilized human IL1B-his at 10 ug/mL (100 ul/well) can bind human IL1R1-Fc. The EC50 of human IL1R1-Fc is 0.198 ug/mL.4. Immobilized human IL1B at 10 ug/mL (100 ul/well) can bind human IL1R1-Fc. The EC50 of human IL1R1-Fc is 0.48 ug/mL.5. Measured by its ability to bind canine IL1B in a functional ELISA.6. Measured by its ability to bind mouse IL1B in a functional ELISA. |
Protein Construction |
A DNA sequence encoding the extracellular domain of human IL1R1 (NP_000868.1) (Met 1-Thr 332) was fused with human IgG1 Fc region at the C-terminus. |
Sequence |
Met 1-Thr 332 |
Fusion tag |
C-Fc |
Accession |
NP_000868.1 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 90 % as determined by reducing SDS-PAGE. |
Endotoxin |
< 1.0 EU per ug as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
63 kDa |
AP Mol Mass |
80-90 kDa |
Formulation |
Lyophilized from sterile PBS, pH 7.4 |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess. |
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