ArtNr |
ELS-PKSH031302-50ug |
Hersteller |
Elabscience
|
Menge |
50ug |
Kategorie |
|
Typ |
Proteins |
Specific against |
Human |
Host |
HEK293 cells |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Transferrin receptor protein 1, TR, TfR, Trfr, T9, p90,CD71,T9,TFR,TFR,TRFR |
Similar products |
CD71, TR, TFR, p90, TRFR, T9, Transferrin receptor protein 1, TfR, Trfr |
Lieferbar |
|
Synonym |
Transferrin receptor protein 1, TR, TfR, Trfr, T9, p90, CD71, T9, TFR, TFR, TRFR |
Storage |
according to manual |
Activity |
Measured by its binding ability in a functional ELISA. Immobilized human CD71 at 10 ug/ml (100 ul/well) can bind human Transferrin. The EC50 of human Transferrin is 5.6 ng/mL. |
Protein Construction |
A DNA sequence encoding the extracellular domain of human TFRC (NP_003225.2) (Cys 89-Phe 760) was expressed with a polyhistidine tag at the N-terminus. |
Sequence |
Cys 89-Phe 760 |
Fusion tag |
N-His |
Accession |
NP_003225.2 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 85 % as determined by reducing SDS-PAGE. |
Endotoxin |
< 1.0 EU per ug as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
77.4 kDa |
Formulation |
Lyophilized from sterile PBS, pH 7.4 |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target. |
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