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Recombinant Human Transferrin Receptor/TFRC Protein (His Tag)(Active)

ArtNr ELS-PKSH031302-50ug
Hersteller Elabscience
Menge 50ug
Kategorie
Typ Proteins
Specific against Human
Host HEK293 cells
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Transferrin receptor protein 1, TR, TfR, Trfr, T9, p90,CD71,T9,TFR,TFR,TRFR
Similar products CD71, TR, TFR, p90, TRFR, T9, Transferrin receptor protein 1, TfR, Trfr
Lieferbar
Synonym
Transferrin receptor protein 1, TR, TfR, Trfr, T9, p90, CD71, T9, TFR, TFR, TRFR
Storage
according to manual
Activity
Measured by its binding ability in a functional ELISA. Immobilized human CD71 at 10 ug/ml (100 ul/well) can bind human Transferrin. The EC50 of human Transferrin is 5.6 ng/mL.
Protein Construction
A DNA sequence encoding the extracellular domain of human TFRC (NP_003225.2) (Cys 89-Phe 760) was expressed with a polyhistidine tag at the N-terminus.
Sequence
Cys 89-Phe 760
Fusion tag
N-His
Accession
NP_003225.2
Shipping
This product is provided as lyophilized powder which is shipped with ice packs.
Purity
> 85 % as determined by reducing SDS-PAGE.
Endotoxin
< 1.0 EU per ug as determined by the LAL method.
Stability and Storage
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months.
Mol Mass
77.4 kDa
Formulation
Lyophilized from sterile PBS, pH 7.4
Reconstitution
Please refer to the printed manual for detailed information.
Background
Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the  peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50ug
Lieferbar: In stock
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