ArtNr |
ELS-PKSH030673-20ug |
Hersteller |
Elabscience
|
Menge |
20ug |
Kategorie |
|
Typ |
Proteins |
Specific against |
Human |
Host |
HEK293 cells |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Endoplasmic Reticulum Resident Protein 27, ER Protein 27, ERp27, ERP27, C12orf46 |
Similar products |
ERP27, C12orf46, ERp27, Endoplasmic Reticulum Resident Protein 27, ER Protein 27 |
Lieferbar |
|
Synonym |
Endoplasmic Reticulum Resident Protein 27, ER Protein 27, ERp27, ERP27, C12orf46 |
Storage |
according to manual |
Protein Construction |
A DNA sequence encoding the human ERP27 (Q96DN0) (Glu26-Pro269) was fused with Fc region of mouse IgG at the C-terminus. |
Sequence |
Glu26-Pro269 |
Fusion tag |
C-Fc |
Accession |
Q96DN0 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 84 % as determined by reducing SDS-PAGE. |
Endotoxin |
< 1.0 EU per ug of the protein as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
53.7 kDa |
Formulation |
Lyophilized from sterile PBS; pH 7.4 |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
ERP27 contains 1 thioredoxin domain and is a noncatalytic member of the protein disulfide isomerase family. Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which catalyze disulfide bonds formation; reduction; or isomerization of newly synthesized proteins in the lumen of the endoplasmic reticulum (ER). They act also as chaperones; and are; therefore; part of a quality-control system for the correct folding of the proteins in the same subcellular compartment. PDI has been found to have moderate effects (25-fold) on the rate of oxidative folding of proteins in vitro. Recombinant Human Protein Disulfide Isomerase is involved in disulphide-bond formation and isomerization; as well as the reduction of disulphide bonds in proteins. Recombinant PDI has been found to have moderate effects (25-fold) on the rate of oxidative folding of proteins in vitro. ERP27 is a widely expressed protein which localizes to the ER and may act as a protease; protein disulfide isomerase; thiol-disulfide oxidase or phospholipase. ERP27 doesn't contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family. |
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