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Recombinant Human PSPH Protein

ArtNr ELS-PKSH030616-20ug
Hersteller Elabscience
Menge 20 ug
Quantity options 100 ug 20 ug
Kategorie
Typ Proteins
Format Lyophilized Powder
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag Untagged
Purity > 84 % as determined by reducing SDS-PAGE.
Sequence Met 1-Glu 225
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias L-3-Phosphoserine Phosphatase, O-Phosphoserine Phosphohydrolase, PSP, PSPH, PSPase, Phosphoserine Phosphatase
Similar products PSP, PSPH, PSPase, Phosphoserine Phosphatase, L-3-Phosphoserine Phosphatase, O-Phosphoserine Phosphohydrolase
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Category
Recombinant Proteins / Others
Manufacturer - Conjugate / Tag
None
Shipping Temperature
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
25 kDa
Observed Molecular Weight
28 kDa
Research Areas
Signal Transduction, metabolism,
Background
Phosphoserine phosphatase (PSPH) belongs to a subfamily of the phosphotransferases. PSPH is the rate-limiting enzyme in l-serine biosynthesis. It has previously been found that Phosphoserine phosphatase (PSPH) plays a role in epidermal homeostasis. Phosphoserine phosphatase (PSP) catalyzes the hydrolysis of phosphoserine to serine. Phosphoserine phosphatase (PSPH) expression has been examined in human-mouse somatic cell hybrids retaining different combination of human chromosomes. Phosphoserine phosphatase (PSPH) is expressed throughout the proliferative layer of the epidermis and hair follicles in rodent and human skin and is highly induced in SCC. In keratinocytes; Phosphoserine phosphatase (PSPH) is a cytoplasmic protein that primarily localizes to endosomes and is present primarily as a homodimer. Knock down of Phosphoserine phosphatase (PSPH) dramatically diminished SCC cell proliferation and cyclin D1 levels in the presence of exogenous of l-serine production suggesting a non-canonical role for Phosphoserine phosphatase (PSPH) in epithelial carcinogenesis. Phosphoserine phosphatase (PSPH) is highly induced in proliferative normal keratinocytes and in skin tumors. Phosphoserine phosphatase (PSPH) appears to be critical for the proliferation of SCC cells; however; this phenomenon may not involve the phosphoserine metabolic pathway.
Endotoxin
Please contact us for more information.
Reconstitution
Please refer to the printed manual for detailed information.
Formulation
Lyophilized from sterile PBS, pH 7.5
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Activity
Not validated for activity

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 20 ug
Lieferbar: In stock
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