ArtNr |
E-AB-40132-200 |
Hersteller |
Elabscience
|
Menge |
200uL |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
IHC |
Specific against |
Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
CD3 epsilon, CD3e, CD3e antigen epsilon polypeptide (TiT3 complex), CD3E antigen epsilon polypeptide, CD3E antigen, epsilon subunit, CD3e molecule epsilon, CD3e molecule, epsilon (CD3 TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3E, IMD18, T |
Similar products |
CD3E, T3E, T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, epsilon subunit, TCRE, CD3E antigen, CD3 epsilon, CD3E antigen epsilon polypeptide, CD3e molecule epsilon, T cell antigen receptor complex epsilon subunit of T3, T cell surface antigen T3/Leu 4 epsilon chain, CD3e molecule, IMD18, CD3e antigen epsilon polypeptide (TiT3 complex), epsilon (CD3 TCR complex), epsilon (CD3-TCR complex), T cell surface glycoprotein CD3 epsilon chain |
Lieferbar |
|
Research Areas |
Immunology, Stem cells |
Synonyms |
CD3 epsilon, CD3e, CD3e antigen epsilon polypeptide (TiT3 complex), CD3E antigen epsilon polypeptide, CD3E antigen, epsilon subunit, CD3e molecule epsilon, CD3e molecule, epsilon (CD3 TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3E, IMD18, T cell antigen receptor complex epsilon subunit of T3, T cell surface antigen T3/Leu 4 epsilon chain, T cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain, T3E, TCRE |
Swissprot |
P07766 |
Background |
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell developement. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128). |
Concentration |
2 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant human CD3E protein |
Buffer |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method |
Affinity purification |
Dilution |
IHC 1:50-1:100 |
Conjugation |
Unconjugated |
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