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P21 Polyclonal Antibody

P21 Polyclonal Antibody

ArtNr	E-AB-40097-20
Hersteller	Elabscience
Menge	20uL
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Blastoma Carcinoma Hematology Lymphoma Melanoma Sarcoma Cell Biology Cell Status Apoptosis Western Blot Senescence Proliferation Primary Antibodies By Organ Lung Cancer Skin Cancer Bladder Cancer Breast Cancer
Typ	Antibody Polyclonal
Applikationen	WB
Specific against	Human
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CDKI, CDKN1A-interacting zinc finger protein 1, Cip1-interacting zinc finger protein, CIZ1, CIZ1, cyclin dependent inhibitor 1A, LSFR1, Melanoma differentiation-associated protein, NP94, Nuclear protein NP94, OPHN3, P21, Zinc finger protein 356, ZNF356
Similar products	CIZ1, Melanoma differentiation-associated protein, OPHN3, P21, LSFR1, NP94, ZNF356, CDKN1A-interacting zinc finger protein 1, Cip1-interacting zinc finger protein, CDKI, cyclin dependent inhibitor 1A, Nuclear protein NP94, Zinc finger protein 356
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Research Areas	Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction
Synonyms	CDKI, CDKN1A-interacting zinc finger protein 1, Cip1-interacting zinc finger protein, CIZ1, CIZ1, cyclin dependent inhibitor 1A, LSFR1, Melanoma differentiation-associated protein, NP94, Nuclear protein NP94, OPHN3, P21, Zinc finger protein 356, ZNF356
Swissprot	P38936
Background	May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
Concentration	2 mg/mL
Storage	Store at -20C. Avoid freeze / thaw cycles.
Immunogen	Recombinant Human P21 protein
Buffer	PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Purification Method	Affinity purification
Dilution	WB 1:500-1:1000
Conjugation	Unconjugated
Calculated MW	18kDa
Observed MW	18kDa
Gene ID	1026
Santa Cruz #	sc-471, sc-469, sc-397, sc-756

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Menge: 20uL

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Lieferung vsl. bis 06.09.2024

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