ArtNr |
E-AB-40072-20 |
Hersteller |
Elabscience
|
Menge |
20uL |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
IHC |
Specific against |
Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
CSIF, Cytokine synthesis inhibitory factor, GVHDS, IL 10, IL-10, IL10, IL10, IL10A, Interleukin 10, Interleukin-10, MGC126450, MGC126451, T-cell growth inhibitory factor, TGIF |
Similar products |
IL-10, IL10, Interleukin-10, Cytokine synthesis inhibitory factor, TGIF, Interleukin 10, IL 10, CSIF, IL10A, MGC126450, MGC126451, GVHDS, T-cell growth inhibitory factor |
Lieferbar |
|
Research Areas |
Cancer, Immunology |
Synonyms |
CSIF, Cytokine synthesis inhibitory factor, GVHDS, IL 10, IL-10, IL10, IL10, IL10A, Interleukin 10, Interleukin-10, MGC126450, MGC126451, T-cell growth inhibitory factor, TGIF |
Swissprot |
P18893 |
Background |
Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappaB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. |
Concentration |
2 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant Mouse Interleukin-10 protein |
Buffer |
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4. |
Purification Method |
Affinity purification |
Dilution |
IHC 1:50-1:100 |
Conjugation |
Unconjugated |
Santa Cruz # |
sc-7888 |
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