ArtNr |
E-AB-12372-120 |
Hersteller |
Elabscience
|
Menge |
120uL |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IHC, ELISA |
Specific against |
Human, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Deoxyuridine 5' triphosphate nucleotidohydrolase, nuclear isoform, Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Deoxyuridine triphosphatase, dut, DUT, dUTP nucleotidohydrolase, dUTP pyrophosphatase, dUTPase, FLJ20622 |
Similar products |
dUTPase, DUT, mitochondrial, Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTP pyrophosphatase, dut, Deoxyuridine 5' triphosphate nucleotidohydrolase, Deoxyuridine triphosphatase, dUTP nucleotidohydrolase, nuclear isoform, FLJ20622 |
Lieferbar |
|
Research Areas |
Epigenetics and Nuclear Signaling |
Synonyms |
Deoxyuridine 5' triphosphate nucleotidohydrolase, nuclear isoform, Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Deoxyuridine triphosphatase, dut, DUT, dUTP nucleotidohydrolase, dUTP pyrophosphatase, dUTPase, FLJ20622 |
Swissprot |
P33316 |
Background |
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. |
Concentration |
0.2 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Synthetic peptide of human DUT |
Buffer |
PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
Purification Method |
Affinity purification |
Dilution |
WB 1:200-1:1000, IHC 1:10-1:50 |
Conjugation |
Unconjugated |
Calculated MW |
27kDa |
Gene Accession |
NP_001939 |
Santa Cruz # |
sc-68069, sc-68071, sc-68073 |
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