ArtNr |
E-AB-70371-120 |
Hersteller |
Elabscience
|
Menge |
120uL |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Activator protein 1, AP 1, AP1, cJun, Enhancer Binding Protein AP1, Jun Activation Domain Binding Protein, JUN, Jun oncogene, JUN protein, Jun proto oncogene, JUN, JUNC, Oncogene JUN, p39, Proto oncogene c jun, Proto oncogene cJun, Proto-oncogene c-jun, T |
Similar products |
JUN, Transcription factor AP-1, Activator protein 1, V-jun avian sarcoma virus 17 oncogene homolog, p39, AP1, AP 1, Jun oncogene, Enhancer Binding Protein AP1, Jun Activation Domain Binding Protein, JUN protein, JUNC, Proto oncogene cJun, Transcription Factor AP1, V jun avian sarcoma virus 17 oncogene homolog, vJun Avian Sarcoma Virus 17 Oncogene Homolog, Proto-oncogene c-jun, cJun, Jun proto oncogene, Oncogene JUN, Proto oncogene c jun, Transcription Factor AP 1, V jun sarcoma virus 17 oncogene homolog (avian), V jun sarcoma virus 17 oncogene homolog |
Lieferbar |
|
Research Areas |
Cancer, Epigenetics and Nuclear Signaling, Immunology, Signal Transduction |
Synonyms |
Activator protein 1, AP 1, AP1, cJun, Enhancer Binding Protein AP1, Jun Activation Domain Binding Protein, JUN, Jun oncogene, JUN protein, Jun proto oncogene, JUN, JUNC, Oncogene JUN, p39, Proto oncogene c jun, Proto oncogene cJun, Proto-oncogene c-jun, Transcription Factor AP 1, Transcription factor AP-1, Transcription Factor AP1, V jun avian sarcoma virus 17 oncogene homolog, V jun sarcoma virus 17 oncogene homolog (avian), V jun sarcoma virus 17 oncogene homolog, V-jun avian sarcoma virus 17 oncogene homolog, vJun Avian Sarcoma Virus 17 Oncogene Homolog |
Swissprot |
P05412, P05627, P17325 |
Background |
JUN is also named as c-Jun and AP1, belongs to the bZIP family and Jun subfamily. JUN, the most extensively studied protein of the activator protein-1 (AP-1) complex, is involved in numerous cell activities, such as proliferation, apoptosis, survival, tumorigenesis and tissue morphogenesis. JUN is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. JUN is a basic leucine zipper (bZIP) transcription factor that acts as homo- or heterodimer, binding to DNA and regulating gene transcription. In additon, extracellular signals can induce post-translational modifications of JUN, resulting in altered transcriptional activity and target gene expression. More over, it has uncovered multiple layers of a complex regulatory scheme in which JUN is able to crosstalk, amplify and integrate different signals for tissue development and disease. Jun is predominantly nuclear, ubiquitinated Jun colocalizes with lysosomal proteins. |
Concentration |
1.1 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Human c-Jun. |
Buffer |
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4 |
Purification Method |
Affinity purification |
Dilution |
IHC 1:500-1:2000 |
Conjugation |
Unconjugated |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.