KPNB1 Polyclonal Antibody

IMB 1, IMB1, IMB1, Impnb, Importin 90, Importin beta 1, Importin beta 1 subunit, Importin subunit beta-1, Importin-90, IPOB, Karyopherin beta 1, Karyopherin beta 1 subunit, Karyopherin subunit beta-1, KPNB 1, Kpnb1, MGC2155, MGC2156, MGC2157, NTF 97, NTF97, Nuclear factor P97, Pore targeting complex 97 kDa subunit, PTAC97

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene.

Store at -20C. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

WB 1:200 - 1:2000

81kDa/97kDa