ArtNr |
E-AB-63329-60 |
Hersteller |
Elabscience
|
Menge |
60uL |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
bHLHe75, Class E basic helix-loop-helix protein 75, glucocorticoid receptor interacting protein 1, GRIP 1, GRIP1, hTIF2, MED1, MGC138808, NCoA 2, NCoA-2, Ncoa2, NCOA2, Nuclear receptor coactivator 2, Oncogene FGR, p160, SRC 2, src2, Steroid receptor coact |
Similar products |
GRIP1, NCOA2, MED1, MGC138808, NCoA-2, TIF2, bHLHe75, SRC 2, Nuclear receptor coactivator 2, p160, Class E basic helix-loop-helix protein 75, glucocorticoid receptor interacting protein 1, GRIP 1, hTIF2, NCoA 2, Ncoa2, Oncogene FGR, src2, Steroid receptor coactivator 2, TIF 2, Transcriptional intermediary factor 2 |
Lieferbar |
|
Research Areas |
Cancer, Epigenetics and Nuclear Signaling, Metabolism |
Synonyms |
bHLHe75, Class E basic helix-loop-helix protein 75, glucocorticoid receptor interacting protein 1, GRIP 1, GRIP1, hTIF2, MED1, MGC138808, NCoA 2, NCoA-2, Ncoa2, NCOA2, Nuclear receptor coactivator 2, Oncogene FGR, p160, SRC 2, src2, Steroid receptor coactivator 2, TIF 2, TIF2, Transcriptional intermediary factor 2 |
Swissprot |
Q15596 |
Background |
The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. |
Concentration |
1 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant protein of human NCOA2 |
Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
Purification Method |
Affinity purification |
Dilution |
WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Conjugation |
Unconjugated |
Calculated MW |
159kDa |
Observed MW |
180kDa |
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