ArtNr |
E-AB-63106-60 |
Hersteller |
Elabscience
|
Menge |
60uL |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
C type lectin domain family 4 member L, C-type lectin domain family 4 member L, CD 209, CD209, CD209 antigen, CD209 antigen-like protein A, CD209 molecule, CD209, Cd209a, CDSIGN, CIRE, CLEC4L, DC SIGN, DC SIGN1, DC-SIGN, DC-SIGN1, DCSIGN, Dendritic cell s |
Similar products |
DC-SIGN, CD209, Cd209a, CDSIGN, CLEC4L, DC-SIGN1, MGC129965, CD209 antigen, SIGN-R1, included, C type lectin domain family 4 member L, CD 209, CD209 antigen-like protein A, CD209 molecule, CIRE, DC SIGN1, DCSIGN, Dengue fever, protection against, HIV GP120 Binding Protein, MGC130443, SIGNR5, C-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, DC SIGN, Dendritic cell specific ICAM 3 grabbing nonintegrin 1, Dendritic cell specific ICAM3 grabbing nonintegrin 1, Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin, Dentritic Cell Specific ICAM3 Grabbing Nonintegrin |
Lieferbar |
|
Research Areas |
Cancer, Immunology, Microbiology, Signal Transduction |
Synonyms |
C type lectin domain family 4 member L, C-type lectin domain family 4 member L, CD 209, CD209, CD209 antigen, CD209 antigen-like protein A, CD209 molecule, CD209, Cd209a, CDSIGN, CIRE, CLEC4L, DC SIGN, DC SIGN1, DC-SIGN, DC-SIGN1, DCSIGN, Dendritic cell specific ICAM 3 grabbing nonintegrin 1, Dendritic cell specific ICAM3 grabbing nonintegrin 1, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin, Dengue fever, protection against, included, Dentritic Cell Specific ICAM3 Grabbing Nonintegrin, HIV GP120 Binding Protein, MGC129965, MGC130443, SIGN-R1, SIGNR5 |
Swissprot |
Q9NNX6 |
Background |
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants. |
Concentration |
1 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant protein of human CD209 |
Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
Purification Method |
Affinity purification |
Dilution |
WB 1:200 - 1:500 |
Conjugation |
Unconjugated |
Calculated MW |
4kDa/18kDa/30-45kDa |
Observed MW |
46kDa |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.