ArtNr |
E-AB-60713-60 |
Hersteller |
Elabscience
|
Menge |
60uL |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IF, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Alpha CP2, Alpha-CP2, alphaCP-2, Cbp, CTBP, Heterogeneous nuclear ribonucleoprotein E2, Heterogenous nuclear ribonucleoprotein E2, hnRNP E2, hnRNP-E2, HNRNPE2, Hnrnpx, HNRPE2, Hnrpx, MGC110998, PCBP2, PCBP2, poly(rC) binding protein 2, Poly(rC)-binding pr |
Similar products |
PCBP2, Cbp, CTBP, HNRPE2, MGC110998, hnRNP-E2, Poly(rC)-binding protein 2, Alpha-CP2, Alpha CP2, alphaCP-2, Heterogeneous nuclear ribonucleoprotein E2, Heterogenous nuclear ribonucleoprotein E2, hnRNP E2, HNRNPE2, Hnrnpx, Hnrpx, poly(rC) binding protein 2, Putative heterogeneous nuclear ribonucleoprotein X, rCbinding protein 2 |
Lieferbar |
|
Research Areas |
Cancer, Epigenetics and Nuclear Signaling, Microbiology |
Synonyms |
Alpha CP2, Alpha-CP2, alphaCP-2, Cbp, CTBP, Heterogeneous nuclear ribonucleoprotein E2, Heterogenous nuclear ribonucleoprotein E2, hnRNP E2, hnRNP-E2, HNRNPE2, Hnrnpx, HNRPE2, Hnrpx, MGC110998, PCBP2, PCBP2, poly(rC) binding protein 2, Poly(rC)-binding protein 2, Putative heterogeneous nuclear ribonucleoprotein X, rCbinding protein 2 |
Swissprot |
Q15366 |
Background |
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. |
Concentration |
1 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant protein of human PCBP2 |
Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
Purification Method |
Affinity purification |
Dilution |
WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
Conjugation |
Unconjugated |
Calculated MW |
33kDa/34kDa/35kDa/38kDa |
Observed MW |
37kDa |
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