ArtNr |
E-AB-52592-20 |
Hersteller |
Elabscience
|
Menge |
20uL |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, ELISA |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
IMP 1, IMP, IMPA 1, IMPA, IMPA1, IMPA1, IMPase 1, IMPase, Inositol 1(or 4) monophosphatase, Inositol monophosphatase 1, Inositol monophosphatase, Inositol(myo) 1(or 4) monophosphatase 1, Inositol-1(or 4)-monophosphatase 1, Lithium sensitive myo inositol m |
Similar products |
IMPA1, IMP, IMPA, IMP 1, Inositol monophosphatase 1, IMPA 1, IMPase 1, IMPase, Inositol 1(or 4) monophosphatase, Inositol monophosphatase, Inositol(myo) 1(or 4) monophosphatase 1, Inositol-1(or 4)-monophosphatase 1, Lithium sensitive myo inositol monophosphatase A1, Lithium-sensitive myo-inositol monophosphatase A1 |
Lieferbar |
|
Research Areas |
Cancer, Metabolism, Neuroscience, Signal transduction |
Synonyms |
IMP 1, IMP, IMPA 1, IMPA, IMPA1, IMPA1, IMPase 1, IMPase, Inositol 1(or 4) monophosphatase, Inositol monophosphatase 1, Inositol monophosphatase, Inositol(myo) 1(or 4) monophosphatase 1, Inositol-1(or 4)-monophosphatase 1, Lithium sensitive myo inositol monophosphatase A1, Lithium-sensitive myo-inositol monophosphatase A1 |
Swissprot |
P29218 |
Background |
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1, 4, 5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1, 3-diphosphate, myo-inositol-1, 4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. |
Concentration |
0.72 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Fusion protein of human IMPA1 |
Buffer |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
Purification Method |
Antigen affinity purification |
Dilution |
WB 1:500-1:2000, ELISA 1:5000-1:10000 |
Conjugation |
Unconjugated |
Calculated MW |
30 kDa |
Observed MW |
Refer to figures |
Gene Accession |
BC009565 |
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