Lamin B1 Polyclonal Antibody

ADLD, lamin B1, Lamin-B1, LMN, LMN2, LMNB, Lmnb1, LMNB1, MGC111419, OTTHUMP00000159218

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).

Store at -20C. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:40000

66kDa