ArtNr |
E-AB-30468-120 |
Hersteller |
Elabscience
|
Menge |
120uL |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, ELISA, IHC-P |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
AKT 1, AKT, AKT1, AKT1, MGC99656, PKB, PKB-ALPHA, PRKBA, Protein Kinase B Alpha, Protein kinase B, Proto-oncogene c-Akt, RAC Alpha, RAC, RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha |
Similar products |
AKT, AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinase B, Proto-oncogene c-Akt, RAC-PK-alpha, MGC99656, PKB-ALPHA, PRKBA, AKT 1, Protein Kinase B Alpha, RAC Alpha |
Lieferbar |
|
Research Areas |
Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction |
Synonyms |
AKT 1, AKT, AKT1, AKT1, MGC99656, PKB, PKB-ALPHA, PRKBA, Protein Kinase B Alpha, Protein kinase B, Proto-oncogene c-Akt, RAC Alpha, RAC, RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha |
Swissprot |
P31749 |
Background |
The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. |
Concentration |
1mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Synthesized peptide derived from the N-terminal region of human Akt1 |
Buffer |
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4. |
Purification Method |
Affinity purification |
Dilution |
WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000 |
Conjugation |
Unconjugated |
Calculated MW |
56kDa |
Observed MW |
55kDa |
Santa Cruz # |
sc-7126, sc-1619, sc-1618, sc-55523, sc-8312 |
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