ArtNr |
E-AB-F11330-50 |
Hersteller |
Elabscience
|
Menge |
50 ug |
Quantity options |
1 mg
100 mg
100 ug
25 mg
25 ug
50 ug
500 ug
5 mg
|
Kategorie |
|
Typ |
Antibody Monoclonal |
Applikationen |
FC, Blocking, FA |
Clon |
29E.2A3 |
Specific against |
Human (Homo sapiens) |
Host |
Mouse |
Isotype |
IgG2b Kappa |
Konjugat/Tag |
Unconjugated |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1, |
Similar products |
B7H1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, PD-L1, B7-H, B7-H1, Programmed cell death ligand 1 |
Versandbedingung |
Gekühlt |
Lieferbar |
|
Manufacturer - Category |
Flow Cytometry Antibodies |
Manufacturer - Isotype |
Mouse IgG2b, κ |
Manufacturer - Conjugate / Tag |
None (AF/LE) |
Shipping Temperature |
Ice bag |
Storage Conditions |
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
Background |
CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. |
Concentration |
≥1 mg/mL |
Buffer |
Sterile PBS. < 1.0 EU per mg of the antibody as determined by the LAL method. |
Abbreviation |
PD-L1 |
Clonality |
Monoclonal |
Usage |
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.