ArtNr |
E-AB-64350-120 |
Hersteller |
Elabscience
|
Menge |
120uL |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
1B07, AS, B-4901, B-7 alpha chain, HC class I antigen SHCHA, HLA class I histocompatibility antigen, HLA class I histocompatibility antigen, B alpha chain, HLA-B, HLA-B histocompatibility type, HLAB, leukocyte antigen class I-B, major histocompatibility c |
Similar products |
HLA-B, HLA class I histocompatibility antigen, HLAB, B, AS, class I, MHC class I molecule, major histocompatibility complex, SPDA1, B alpha chain, B-7 alpha chain, 1B07, MHC Class I HLA heavy chain, MHC HLA-B cell surface glycoprotein, MHC class I antigen HLA-B heavy chain, leukocyte antigen class I-B, B-4901, HC class I antigen SHCHA, HLA-B histocompatibility type, MHC class 1 antigen, MHC class I antigen B*7, MHC class I antigen HLA-B alpha chain, MHC HLA-B transmembrane glycoprotein |
Lieferbar |
|
Synonyms |
1B07, AS, B-4901, B-7 alpha chain, HC class I antigen SHCHA, HLA class I histocompatibility antigen, HLA class I histocompatibility antigen, B alpha chain, HLA-B, HLA-B histocompatibility type, HLAB, leukocyte antigen class I-B, major histocompatibility complex, class I, B, MHC class 1 antigen, MHC class I antigen B*7, MHC class I antigen HLA-B alpha chain, MHC class I antigen HLA-B heavy chain, MHC Class I HLA heavy chain, MHC class I molecule, MHC HLA-B cell surface glycoprotein, MHC HLA-B transmembrane glycoprotein, SPDA1 |
Swissprot |
P01889 |
Background |
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. |
Concentration |
1 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
A synthetic peptide of human HLA-B |
Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
Purification Method |
Affinity purification |
Dilution |
WB 1:1000 - 1:2000 |
Conjugation |
Unconjugated |
Calculated MW |
40kDa |
Observed MW |
40kDa |
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