MANF Polyclonal Antibody

Arginine rich mutated in early stage tumors, Arginine rich protein, Arginine-rich protein, ARMET, ARMET protein, ARP, Manf, MANF, Mesencephalic astrocyte derived neurotrophic factor, Mesencephalic astrocyte-derived neurotrophic factor, MGC142148, MGC142150, Protein ARMET

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.

Store at -20C. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

WB 1:500 - 1:2000 IF 1:50 - 1:100

20kDa