ArtNr |
E-AB-61378-200 |
Hersteller |
Elabscience
|
Menge |
200uL |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
IF |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
A beta H J J, AAH, ASP beta hydroxylase, Aspartyl/asparaginyl beta hydroxylase, ASPH, ASPH, BAH, Cardiac junctin, CASQ2BP1, HAAH, Humbug, JCTN, junctin, Peptide aspartate beta dioxygenase |
Similar products |
ASPH, AAH, BAH, CASQ2BP1, HAAH, JCTN, junctin, Peptide aspartate beta dioxygenase, ASP beta hydroxylase, Aspartyl/asparaginyl beta hydroxylase, Humbug, A beta H J J, Cardiac junctin |
Lieferbar |
|
Research Areas |
Cancer, Neuroscience, Signal Transduction |
Synonyms |
A beta H J J, AAH, ASP beta hydroxylase, Aspartyl/asparaginyl beta hydroxylase, ASPH, ASPH, BAH, Cardiac junctin, CASQ2BP1, HAAH, Humbug, JCTN, junctin, Peptide aspartate beta dioxygenase |
Swissprot |
Q12797 |
Background |
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. |
Concentration |
1 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant protein of human ASPH |
Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
Purification Method |
Affinity purification |
Dilution |
IF 1:50 - 1:100 |
Conjugation |
Unconjugated |
Calculated MW |
21-34kDa/83-85kDa |
Observed MW |
Refer to figures |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.