ArtNr |
E-AB-19269-20 |
Hersteller |
Elabscience
|
Menge |
20uL |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
IHC, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Calcium release-activated calcium channel regulator 2A, CRAC channel regulator 2A, CRACR2A, EF hand calcium binding domain 4B, EF hand calcium binding domain containing protein 4B, EF-hand calcium-binding domain-containing protein 4B, EFC4B, EFCAB 4B, Efc |
Similar products |
CRACR2A, EF-hand calcium-binding domain-containing protein 4B, Calcium release-activated calcium channel regulator 2A, FLJ33805, MGC4266, Efcab4b, EFC4B, CRAC channel regulator 2A, EF hand calcium binding domain 4B, EF hand calcium binding domain containing protein 4B, EFCAB 4B |
Lieferbar |
|
Research Areas |
Signal transduction |
Synonyms |
Calcium release-activated calcium channel regulator 2A, CRAC channel regulator 2A, CRACR2A, EF hand calcium binding domain 4B, EF hand calcium binding domain containing protein 4B, EF-hand calcium-binding domain-containing protein 4B, EFC4B, EFCAB 4B, Efcab4b, FLJ33805, MGC4266 |
Swissprot |
Q9BSW2 |
Background |
Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. |
Concentration |
0.84 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Fusion protein of human CRACR2A |
Buffer |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
Purification Method |
Antigen affinity purification |
Dilution |
IHC 1:50-1:200, ELISA 1:5000-1:10000 |
Conjugation |
Unconjugated |
Gene Accession |
BC004524 |
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