IFI35 Polyclonal Antibody

FLJ21753, IFI 35, Ifi-35, Ifi35, IFP 35, IFP35, IN35, IN35, Interferon induced 35 kDa protein, Interferon-induced 35 kDa protein, OTTHUMP00000236626, OTTHUMP00000236627

The Interferon family of proteins are able to alter the expression of a variety of target genes, thereby controlling various events within the cell. IFI-35 (Interferon-induced 35 kDa protein), also known as IFP35, is a 286 amino acid interferon-induced protein. Localized to the nucleus and expressed in macrophages, fibroblasts and epithelial cells, IFI-35 is a leucine zipper protein that can form homodimers, but, unlike most leucine zipper proteins, cannot bind DNA. Upon induction by IFN-alpha, IFI-35 associates with Nmi (N-Myc-interacting protein), resulting in the formation of a high molecular weight complex that is thought to play a role in IFN-alpha signaling and cellular responses. Once complexed with Nmi, IFI-35 is unable to be degraded by the proteasome, suggesting that IFI-35 is protected from degradation only when needed by IFN-alpha. Two isoforms of IFI-35 exist due to alternative splicing events.

Store at -20C. Avoid freeze / thaw cycles.

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

IHC 1:30-1:150, ELISA 1:5000-1:10000

NP001317159