ArtNr |
CSB-EP007140RA-1 |
Hersteller |
Cusabio
|
Menge |
1mg |
Quantity options |
1mg
10ug
100ug
20ug
200ug
50ug
500ug
|
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Host |
E.coli |
Purity |
Greater than 90% as determined by SDS-PAGE. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
DPPXDipeptidyl aminopeptidase-related proteinDipeptidyl peptidase 6Dipeptidyl peptidase IV-like proteinDipeptidyl peptidase VI ;DPP VI |
Lieferbar |
|
Research Areas |
Others |
Uniprot ID |
P46101 |
Gene Names |
DPP6 |
Organism |
Rattus norvegicus (Rat) |
AA Sequence |
LTPAEDTSLSQKKKVTVEDLFSEDFKIHDPEAKWI SDKEFIYRERKGSVILRNVETNNSTVLIEGKKIES LRAIRYEISPDKEYALFSYNVEPVYQHSHTGYYVL SKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIF IFENNIYYCAHVGKQAIRVVSTGKEGVIYNGLSDW LYEEEILKSHIAHWWSPDGTRLAYATINDSRVPLM ELPTYTGSVYPTVKPYHYPKAGSENPSISLHVIGL NGPTHDLEMMPPDDPRMREYYITMVKWATSTKVAV TWLNRAQNVSILTLCDATTGVCTKKHEDESEAWLH RQNEEPVFSKDGRKFFFVRAIPQGGRGKFYHITVS SSQPNSSNDNIQSITSGDWDVTEILTYDEKRNKLY FLSTEDLPRRRHLYSANTVDDFNRQCLSCDLVENC TYVSASFSHNMDFFLLKCEGPGVPTVTVHNTTDKR RMFDLEANEQVQKAIYDRQMPKIEYRKIEVEDYSL PMQILKPATFTDTAHYPLLLVVDGTPGSQSVSERF EVTWETVLVSSHGAVVVKCDGRGSGFQGTKLLHEV RRRLGFLEEKDQMEAVRTMLKEQYIDKTRVAVFGK DYGGYLSTYILPAKGENQGQTFTCGSALSPITDFK LYASAFSERYLGLHGLDNRAYEMTKLAHRVSALED QQFLIIHATADEKIHFQHTAELITQLIKGKANYSL QIYPDESHYFHSVALKQHLYRSIIGFFVECFRIQD KLPTATAKEDEEED |
Expression Region |
111-859aa |
Sequence Info |
Extracellular Domain |
Source |
E.coli |
Tag Info |
N-terminal 6xHis-tagged |
MW |
89.6 kDa |
Alternative Name(s) |
DPPXDipeptidyl aminopeptidase-related proteinDipeptidyl peptidase 6Dipeptidyl peptidase IV-like proteinDipeptidyl peptidase VI ; DPP VI |
Relevance |
Promotes cell surface expression of the potassium channel KCND2 . Modulates the activity and gating characteristics of the potassium channel KCND2 . Has no dipeptidyl aminopeptidase activity . |
Reference |
The dipeptidyl-peptidase-like protein DPP6 determines the unitary conductance of neuronal Kv4.2 channels.Kaulin Y.A., De Santiago-Castillo J.A., Rocha C.A., Nadal M.S., Rudy B., Covarrubias M.J. Neurosci. 29:3242-3251(2009) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Form |
Liquid or Lyophilized powder |
Buffer |
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Reconstitution |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20C/-80C. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Promotes cell surface expression of the potassium channel KCND2 |
Subcellular Location |
Cell membrane, Single-pass type II membrane protein |
Protein Families |
Peptidase S9B family |
Tissue Specificity |
Detected in brain cortex, hippocampus, thalamus and cerebellum granule cells (at protein level) (PubMed:16123112). Isoform DPPX-S is expressed in brain and some peripheral tissues including kidney, ovary, and testis; in contrast isoform DPPX-L is expressed almost exclusively in brain. |
Tag Information |
N-terminal 6xHis-tagged |
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