ArtNr |
CSB-YP021338HU-1 |
Hersteller |
Cusabio
|
Menge |
1mg |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Host |
Yeast |
Purity |
Greater than 90% as determined by SDS-PAGE. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
CD172 antigen-like family member B,Signal-regulatory protein beta-2,Short name:SIRP-b2,Short name:SIRP-beta-2,CD_antigen: CD172g |
Lieferbar |
|
Research Topic |
Immunology |
Uniprot ID |
Q9P1W8 |
Gene Names |
SIRPG |
Organism |
Homo sapiens (Human) |
AA Sequence |
EEELQMIQPEKLLLVTVGKTATLHCTVTSLLPVGP VLWFRGVGPGRELIYNQKEGHFPRVTTVSDLTKRN NMDFSIRISSITPADVGTYYCVKFRKGSPENVEFK SGPGTEMALGAKPSAPVVLGPAARTTPEHTVSFTC ESHGFSPRDITLKWFKNGNELSDFQTNVDPTGQSV AYSIRSTARVVLDPWDVRSQVICEVAHVTLQGDPL RGTANLSEAIRVPPTLEVTQQPMRVGNQVNVTCQV RKFYPQSLQLTWSENGNVCQRETASTLTENKDGTY NWTSWFLVNISDQRDDVVLTCQVKHDGQLAVSKRL ALEVTVHQKDQSSDATP |
Expression Region |
29-360aa |
Sequence Info |
Extracellular Domain |
Source |
Yeast |
Tag Info |
N-terminal 6xHis-tagged |
MW |
38.8 kDa |
Alternative Name(s) |
CD172 antigen-like family member B Signal-regulatory protein beta-2 Short name:SIRP-b2 Short name:SIRP-beta-2 CD_antigen: CD172g |
Relevance |
Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. |
Reference |
"Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation."Piccio L., Vermi W., Boles K.S., Fuchs A., Strader C.A., Facchetti F., Cella M., Colonna M.Blood 105:2421-2427(2005) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. |
Subcellular Location |
Membrane, Single-pass type I membrane protein |
Tissue Specificity |
Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection. |
Paythway |
Osteoclastdifferentiation |
Tag Information |
N-terminal 6xHis-tagged |
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