Recombinant Mouse Microtubule-associated protein tau(Mapt)

Neuroscience

Not Test

Mus musculus (Mouse)

ADPRQEFDTMEDHAGDYTLLQDQEGDMDHGLKESP PQPPADDGAEEPGSETSDAKSTPTAEDVTAPLVDE RAPDKQAAAQPHTEIPEGITAEEAGIGDTPNQEDQ AAGHVTQGRREGQAPDLGTSDWTRQQVSSMSGAPL LPQGLREATCQPSGTRPEDIEKSHPASELLRRGPP QKEGWGQDRLGSEEEVDEDLTVDESSQDSPPSQAS LTPGRAAPQAGSGSVCGETASVPGLPTEGSVPLPA DFFSKVSAETQASQPEGPGTGPMEEGHEAAPEFTF HVEIKASTPKEQDLEGATVVGVPGEEQKAQTQGPS VGKGTKEASLQEPPGKQPAAGLPGRPVSRVPQLKA RVASKDRTGNDEKKAKTSTPSCAKAPSHRPCLSPT RPTLGSSDPLIKPSSPAVSPEPATSPKHVSSVTPR NGSPGTKQMKLKGADGKTGAKIATPRGAASPAQKG TSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSS PGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPK SPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQ PGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGG SVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEV KSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETH KLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLS NVSSTGSIDMVDSPQLATLADEVSASLAKQGL

2-733aa

78.1 kDa

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Greater than 90% as determined by SDS-PAGE.

Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.

May be involved in the pathogenesis of cytoplasmic inclusions (as Mallory bodies) in livers of mice chronically intoxicated with Griseofulvin or DDC (3, 5-diethoxycarbonyl-2, 4-dihydrocollidine), a model for human alcoholic hepatitis. Alteration of Tau (abnormal phosphorylation and cross-linking) could contribute to Mallory bodies formation and disturbance of microtubule function in alcoholic liver disease.

Expressed in neurons and at a lower level in the liver and kidney. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.