Hersteller |
Cusabio
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Menge |
200ug |
Host |
Yeast |
ArtNr |
CSB-YP011930HU-200 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Alias |
Janus kinase 1,Short name:,JAK-1 |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Research Topic |
Cancer |
Uniprot ID |
P23458 |
Gene Names |
JAK1 |
Organism |
Homo sapiens (Human) |
AA Sequence |
EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEG HFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHI ADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKL IMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICK GMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGL TKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFY IASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGP THGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMR KCWEFQPSNRTSFQNLIEGFEALLK |
Expression Region |
850-1154aa |
Sequence Info |
Partial |
Source |
Yeast |
Tag Info |
N-terminal 6xHis-tagged |
MW |
36.9 kDa |
Alternative Name(s) |
Janus kinase 1 Short name: JAK-1 |
Relevance |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. |
Reference |
"Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase." Wilks A.F., Harpur A.G., Kurban R.R., Ralph S.J., Zuercher G., Ziemiecki A.Mol. Cell. Biol. 11:2057-2065(1991) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway |
Subcellular Location |
Endomembrane system, Peripheral membrane protein |
Protein Families |
Protein kinase superfamily, Tyr protein kinase family, JAK subfamily |
Tissue Specificity |
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. |
Paythway |
Jak-STATsignalingpathway |
Tag Information |
N-terminal 6xHis-tagged |
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