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Recombinant Human Galactocerebrosidase(GALC)

Recombinant Human Galactocerebrosidase(GALC)

ArtNr	CSB-YP009196HU-200
Hersteller	Cusabio
Menge	200ug
Quantity options	1mg 10ug 100ug 20ug 200ug 50ug 500ug
Kategorie	Oncology Peptides & Proteins Recombinant Proteins By Organ Colorectal Cancer
Typ	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	other
Host	Yeast
Purity	Greater than 90% as determined by SDS-PAGE.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Galactocerebroside beta-galactosidase,Galactosylceramidase,Galactosylceramide beta-galactosidase
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Research Topic	Cardiovascular
Uniprot ID	P54803
Gene Names	GALC
Organism	Homo sapiens (Human)
AA Sequence	YVLDDSDGLGREFDGIGAVSGGGATSRLLVNYPEP YRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGT EPSHMHYALDENYFRGYEWWLMKEAKKRNPNITLI GLPWSFPGWLGKGFDWPYVNLQLTAYYVVTWIVGA KRYHDLDIDYIGIWNERSYNANYIKILRKMLNYQG LQRVKIIASDNLWESISASMLLDAELFKVVDVIGA HYPGTHSAKDAKLTGKKLWSSEDFSTLNSDMGAGC WGRILNQNYINGYMTSTIAWNLVASYYEQLPYGRC GLMTAQEPWSGHYVVESPVWVSAHTTQFTQPGWYY LKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHS KCIRPFLPYFNVSQQFATFVLKGSFSEIPELQVWY TKLGKTSERFLFKQLDSLWLLDSDGSFTLSLHEDE LFTLTTLTTGRKGSYPLPPKSQPFPSTYKDDFNVD YPFFSEAPNFADQTGVFEYFTNIEDPGEHHFTLRQ VLNQRPITWAADASNTISIIGDYNWTNLTIKCDVY IETPDTGGVFIAGRVNKGGILIRSARGIFFWIFAN GSYRVTGDLAGWIIYALGRVEVTAKKWYTLTLTIK GHFASGMLNDKSLWTDIPVNFPKNGWAAIGTHSFE FAQFDNFLVEATR
Expression Region	43-685aa
Sequence Info	Full Length of Mature Protein
Source	Yeast
Tag Info	N-terminal 6xHis-tagged
MW	74.8 kDa
Alternative Name(s)	Galactocerebroside beta-galactosidase Galactosylceramidase Galactosylceramide beta-galactosidase
Relevance	Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
Reference	"Structure and organization of the human galactocerebrosidase (GALC) gene."Luzi P., Rafi M.A., Wenger D.A.Genomics 26:407-409(1995)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
Involvement in disease	Leukodystrophy, globoid cell (GLD)
Subcellular Location	Lysosome
Protein Families	Glycosyl hydrolase 59 family
Tissue Specificity	Detected in urine. Detected in testis, brain and placenta (at protein level). Detected in kidney and liver.
Tag Information	N-terminal 6xHis-tagged

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