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Recombinant Human Angiogenin(ANG),partial

Recombinant Human Angiogenin(ANG),partial

ArtNr	CSB-RP057294h-500
Hersteller	Cusabio
Menge	500ug
Kategorie	Neuroscience Neural Signaling Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Host	E.coli
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Ribonuclease 5
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Research Topic	Signal Transduction
Uniprot ID	P03950
Gene Names	RNASE5
Organism	Homo sapiens (Human)
AA Sequence	DNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLT SPCKDINTFIHGNKRSIKAICENKNGNPHRENLRI SKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVA CENGLPVHLDQSIFRRP
Expression Region	26-147aa
Sequence Info	Partial
Source	E.coli
Tag Info	N-terminal 6xHis-tagged
MW	18 kDa
Alternative Name(s)	Ribonuclease 5
Relevance	Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Reference	"Diversifying selection of the tumor-growth promoter angiogenin in primate evolution." Zhang J., Rosenberg H.F. Mol. Biol. Evol. 19:438-445(2002)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Involvement in disease	Amyotrophic lateral sclerosis 9 (ALS9)
Subcellular Location	Cytoplasmic vesicle, secretory vesicle lumen, Secreted, Nucleus, Nucleus, nucleolus
Protein Families	Pancreatic ribonuclease family
Tissue Specificity	Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.

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