ArtNr |
CSB-EP852773HU-50 |
Hersteller |
Cusabio
|
Menge |
50ug |
Quantity options |
1mg
10ug
100ug
20ug
200ug
50ug
500ug
|
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Host |
E.coli |
Konjugat/Tag |
GST |
Purity |
Greater than 90% as determined by SDS-PAGE. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
WD repeat-containing protein 45 |
Lieferbar |
|
Research Topic |
Cell Biology |
Uniprot ID |
Q9Y484 |
Gene Names |
WDR45 |
Organism |
Homo sapiens (Human) |
AA Sequence |
MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVE PLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGS SPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPV LSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDT RDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLA STKPGTSSAPFTINAHQSDIACVSLNQPGTVVASA SQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINF SHDSSFLCASSDKGTVHIFALKDTRLNRRSALARV GKVGPMIGQYVDSQWSLASFTVPAESACICAFGRN TSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDV YLDICDDDDF |
Expression Region |
1-360aa |
Sequence Info |
Full Length |
Source |
E.coli |
Tag Info |
N-terminal GST-tagged |
MW |
66.9 kDa |
Alternative Name(s) |
WD repeat-containing protein 45 |
Relevance |
Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. |
Reference |
"WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy." Proikas-Cezanne T., Waddell S., Gaugel A., Frickey T., Lupas A., Nordheim A. Oncogene 23:9314-9325(2004) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. |
Involvement in disease |
Neurodegeneration with brain iron accumulation 5 (NBIA5) |
Protein Families |
WD repeat SVP1 family |
Tissue Specificity |
Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta. Expression is down-regulated in pancreatic and in kidney tumors. |
Tag Information |
N-terminal GST-tagged |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.