ArtNr |
CSB-EP851443MOV-200 |
Hersteller |
Cusabio
|
Menge |
200ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Host |
E.coli |
Purity |
Greater than 90% as determined by SDS-PAGE. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
IgG Fc fragment receptor transporter alpha chainNeonatal Fc receptor |
Lieferbar |
|
Research Topic |
Others |
Uniprot ID |
Q8SPV9 |
Gene Names |
FCGRT |
Organism |
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
AA Sequence |
AESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQY LSYDSLRGQAEPCGAWVWENQVSWYWEKETTDLRI KEKLFLEAFKALGGKGPYTLQGLLGCELSPDNTSV PTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQR WQQQDKAANKELTFLLFSCPHRLREHLERGRGNLE WKEPPSMRLKARPGNPGFSVLTCSAFSFYPPELQL RFLRNGMAAGTGQGDFGPNSDGSFHASSSLTVKSG DEHHYCCIVQHAGLAQPLRVELETPAKSS |
Expression Region |
24-297aa |
Sequence Info |
Extracellular Domain |
Source |
E.coli |
Tag Info |
N-terminal 6xHis-SUMO-tagged |
MW |
46.4 kDa |
Alternative Name(s) |
IgG Fc fragment receptor transporter alpha chainNeonatal Fc receptor |
Relevance |
Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus . |
Reference |
Binding of human IgG to cynomolgus FcR.Namenuk A.K., Hong K., Meng Y.G., Shields R.L., Cromwell M.E.M., Presta L.G. |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus (By similarity). |
Subcellular Location |
Cell membrane, Single-pass type I membrane protein |
Protein Families |
Immunoglobulin superfamily |
Tag Information |
N-terminal 6xHis-SUMO-tagged |
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