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Recombinant Human 1-acylglycerol-3-phosphate O-acyltransferase ABHD5(ABHD5)

ArtNr CSB-EP819884HU-10
Hersteller Cusabio
Menge 10ug
Quantity options 1mg 10ug 100ug 20ug 200ug 50ug 500ug
Kategorie
Typ Proteins Recombinant
Format Liquid or Lyophilized powder
Specific against other
Host E.coli
Purity Greater than 90% as determined by SDS-PAGE.
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Abhydrolase domain-containing protein 5,Lipid droplet-binding protein CGI-58
Lieferbar
Research Topic
Cancer
Uniprot ID
Q8WTS1
Gene Names
ABHD5
Organism
Homo sapiens (Human)
AA Sequence
AAEEEEVDSADTGERSGWLTGWLPTWCPTSISHLK EAEEKMLKCVPCTYKKEPVRISNGNKIWTLKFSHN ISNKTPLVLLHGFGGGLGLWALNFGDLCTNRPVYA FDLLGFGRSSRPRFDSDAEEVENQFVESIEEWRCA LGLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILV EPWGFPERPDLADQDRPIPVWIRALGAALTPFNPL AGLRIAGPFGLSLVQRLRPDFKRKYSSMFEDDTVT EYIYHCNVQTPSGETAFKNMTIPYGWAKRPMLQRI GKMHPDIPVSVIFGARSCIDGNSGTSIQSLRPHSY VKTIAILGAGHYVYADQPEEFNQKVKEICDTVD
Expression Region
2-349aa
Sequence Info
Full Length of Mature Protein
Source
E.coli
Tag Info
N-terminal 6xHis-SUMO-tagged
MW
55 kDa
Alternative Name(s)
Abhydrolase domain-containing protein 5
Lipid droplet-binding protein CGI-58
Relevance
Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation.
Reference
"Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome."Lefevre C., Jobard F., Caux F., Bouadjar B., Karaduman A., Heilig R., Lakhdar H., Wollenberg A., Verret J.-L., Weissenbach J., Oezguec M., Lathrop M., Prud'homme J.-F., Fischer J.Am. J. Hum. Genet. 69:1002-1012(2001)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage Buffer
Tris-based buffer, 50% glycerol
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function
Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis
Involvement in disease
Chanarin-Dorfman syndrome (CDS)
Subcellular Location
Cytoplasm, Lipid droplet
Protein Families
Peptidase S33 family, ABHD4/ABHD5 subfamily
Tissue Specificity
Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level).
Tag Information
N-terminal 6xHis-SUMO-tagged

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 10ug
Lieferbar: In stock
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