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Recombinant Human Toll-like receptor 7(TLR7),partial

Recombinant Human Toll-like receptor 7(TLR7),partial

ArtNr	CSB-EP023606HU-1
Hersteller	Cusabio
Menge	1mg
Kategorie	Neuroscience Neuroinflammation Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	other
Konjugat/Tag	Myc
Purity	Greater than 85% as determined by SDS-PAGE.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
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Research areas	Epigenetics and Nuclear Signaling
Target / Protein	TLR7
Biologically active	Not Test
Expression system	E.coli
Species of origin	Homo sapiens (Human)
Uniprot ID	Q9NYK1
AA Sequence	HLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFI VYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEE RDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTE NFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKF LQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALAT DNHVAYSQVFKETV
Tag Info	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Expression Region	861-1049aa
Protein length	Partial
MW	29.5 kDa
Relevance	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
References	"Three novel mammalian Toll-like receptors: gene structure, expression, and evolution." Du X., Poltorak A., Wei Y., Beutler B. Eur. Cytokine Netw. 11:362-371(2000)
Purity	Greater than 85% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Subcellular Location	Endoplasmic reticulum membrane, Single-pass type I membrane protein, Endosome, Lysosome, Cytoplasmic vesicle, phagosome
Protein Families	Toll-like receptor family
Tissue Specificity	Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
Paythway	Toll-likereceptorsignalingpathway
Tag Information	N-terminal 10xHis-tagged and C-terminal Myc-tagged

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