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Recombinant Human NF-kappa-B-repressing factor(NKRF),partial

Recombinant Human NF-kappa-B-repressing factor(NKRF),partial

ArtNr	CSB-EP015836HU-50
Hersteller	Cusabio
Menge	50ug
Quantity options	1mg 10ug 100ug 20ug 200ug 50ug 500ug
Kategorie	Neuroscience Neuroinflammation Metabolism Diabetes Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	other
Purity	Greater than 90% as determined by SDS-PAGE.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
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Research Topic	Cell Biology
Uniprot ID	O15226
Gene Names	NKRF
Organism	Homo sapiens (Human)
AA Sequence	ILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCD GQNPPKKQAGSKFHARPRFEPVHFVASSSKDERQE DPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQ DGNSQYCDSSGFILTKDQPVTANMYFDSGNPAPST TSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLT ATIWKNLSNPEMTSGSDKINYTYMLTRCIQACKTN PEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQN IYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVV RRKFKHTFGEDLVVCQIGMSSYEFPPALKPPEDLV VLGKDASGQPIFNASAKHWTNFVITENANDAIGIL NNSASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLA EGYGTKKTSKHAAADEALKILQKTQPTYPSVKSSQ CHTGSSPRGSGKKKDIKDLVVYENSSNPVCTLNDT AQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAV GVKKTVKYEAAGEAVKTLKKTQPTVINNLKKGAVE DVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMG WTGGGLGKSGEGIREPISVKEQHKREGLGLDVERV NKIAKRDIEQIIRNYARSESHTDLTFSRELTNDER KQIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKED LLDQLKQEGQVGHYELVMPQ
Expression Region	4-688aa
Sequence Info	Partial
Source	E.coli
Tag Info	N-terminal 6xHis-tagged
MW	81.1 kDa
Alternative Name(s)	Protein ITBA4Transcription factor NRF
Relevance	Interacts with a specific negative regulatory elent (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.
Reference	Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.
Subcellular Location	Nucleus, nucleolus
Tissue Specificity	Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.
Tag Information	N-terminal 6xHis-tagged

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