ArtNr |
CSB-EP010376MO-10 |
Hersteller |
Cusabio
|
Menge |
10ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Host |
E.coli |
Konjugat/Tag |
GST |
Purity |
Greater than 90% as determined by SDS-PAGE. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
H1 VAR.3Histone H1a ;H1a |
Lieferbar |
|
Research Topic |
Others |
Uniprot ID |
P43275 |
Gene Names |
Hist1h1a |
Organism |
Mus musculus (Mouse) |
AA Sequence |
SETAPVAQAASTATEKPAAAKKTKKPAKAAAPRKK PAGPSVSELIVQAVSSSKERSGVSLAALKKSLAAA GYDVEKNNSRIKLGLKSLVNKGTLVQTKGTGAAGS FKLNKKAESKAITTKVSVKAKASGAAKKPKKTAGA AAKKTVKTPKKPKKPAVSKKTSKSPKKPKVVKAKK VAKSPAKAKAVKPKASKAKVTKPKTPAKPKKAAPK KK |
Expression Region |
2-213aa |
Sequence Info |
Full Length of Mature Protein |
Source |
E.coli |
Tag Info |
N-terminal GST-tagged |
MW |
48.7 kDa |
Alternative Name(s) |
H1 VAR.3Histone H1a ; H1a |
Relevance |
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin rodeling, nucleosome spacing and DNA methylation . |
Reference |
Citrullination regulates pluripotency and histone H1 binding to chromatin.Christophorou M.A., Castelo-Branco G., Halley-Stott R.P., Oliveira C.S., Loos R., Radzisheuskaya A., Mowen K.A., Bertone P., Silva J.C., Zernicka-Goetz M., Nielsen M.L., Gurdon J.B., Kouzarides T.Nature 507:104-108(2014) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). |
Subcellular Location |
Nucleus, Chromosome |
Protein Families |
Histone H1/H5 family |
Tissue Specificity |
Restricted to thymus, testis and spleen. Present also in lymphocytic and neuronal cells. Increases in testis starting with a low level at day 5 and reaching high concentrations in 20-day old and adult animals. |
Tag Information |
N-terminal GST-tagged |
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