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Recombinant Mouse Histone H1.1(H1-1)

Recombinant Mouse Histone H1.1(H1-1)

ArtNr	CSB-EP010376MO-10
Hersteller	Cusabio
Menge	10ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	other
Host	E.coli
Konjugat/Tag	GST
Purity	Greater than 90% as determined by SDS-PAGE.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	H1 VAR.3Histone H1a ;H1a
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Research Topic	Others
Uniprot ID	P43275
Gene Names	Hist1h1a
Organism	Mus musculus (Mouse)
AA Sequence	SETAPVAQAASTATEKPAAAKKTKKPAKAAAPRKK PAGPSVSELIVQAVSSSKERSGVSLAALKKSLAAA GYDVEKNNSRIKLGLKSLVNKGTLVQTKGTGAAGS FKLNKKAESKAITTKVSVKAKASGAAKKPKKTAGA AAKKTVKTPKKPKKPAVSKKTSKSPKKPKVVKAKK VAKSPAKAKAVKPKASKAKVTKPKTPAKPKKAAPK KK
Expression Region	2-213aa
Sequence Info	Full Length of Mature Protein
Source	E.coli
Tag Info	N-terminal GST-tagged
MW	48.7 kDa
Alternative Name(s)	H1 VAR.3Histone H1a ; H1a
Relevance	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin rodeling, nucleosome spacing and DNA methylation .
Reference	Citrullination regulates pluripotency and histone H1 binding to chromatin.Christophorou M.A., Castelo-Branco G., Halley-Stott R.P., Oliveira C.S., Loos R., Radzisheuskaya A., Mowen K.A., Bertone P., Silva J.C., Zernicka-Goetz M., Nielsen M.L., Gurdon J.B., Kouzarides T.Nature 507:104-108(2014)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Subcellular Location	Nucleus, Chromosome
Protein Families	Histone H1/H5 family
Tissue Specificity	Restricted to thymus, testis and spleen. Present also in lymphocytic and neuronal cells. Increases in testis starting with a low level at day 5 and reaching high concentrations in 20-day old and adult animals.
Tag Information	N-terminal GST-tagged

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