Recombinant Human Fibrinogen beta chain(FGB), partial

Cardiovascular

FGB

GHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAA ATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQE ALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMY LLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYID ETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQ MEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEM YLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGS VDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWL GNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGF TVQNEANKYQISVNKYRGTAGNALMDGASQLMGEN RTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDG GGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDG VVWMNWKGSWYSMRKMSMKIRPFFPQQ

Partial

N-terminal 6xHis-tagged

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Greater than 90% as determined by SDS-PAGE.

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Secreted

Complementandcoagulationcascades