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Recombinant Human Prothrombin(F2)

Recombinant Human Prothrombin(F2)

ArtNr	CSB-EP007923HU-50
Hersteller	Cusabio
Menge	50ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	other
Host	E.coli
Purity	Greater than 90% as determined by SDS-PAGE.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Coagulation factor II,Cleaved into the following 4 chains:,Activation peptide fragment 1,Activation peptide fragment 2,Thrombin light chain,Thrombin heavy chain
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Research Topic	Cardiovascular
Uniprot ID	P00734
Gene Names	F2
Organism	Homo sapiens (Human)
AA Sequence	ANTFLEEVRKGNLERECVEETCSYEEAFEALESST ATDVFWAKYTACETARTPRDKLAACLEGNCAEGLG TNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHP GADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSI PVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRG QQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNS AVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDL NYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTF FNPRTFGSGEADCGLRPLFEKKSLEDKTERELLES YIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGA SLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGK HSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYK GRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVER PVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDS GGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFY THVFRLKKWIQKVIDQFGE
Expression Region	44-622aa
Sequence Info	Full Length of Mature Protein
Source	E.coli
Tag Info	N-terminal 6xHis-SUMO-tagged
MW	81.3 kDa
Alternative Name(s)	Coagulation factor II Cleaved into the following 4 chains: Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain
Relevance	Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
Reference	"Nucleotide sequence of the gene for human prothrombin."Degen S.J.F., Davie E.W.Biochemistry 26:6165-6177(1987)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
Involvement in disease	Factor II deficiency (FA2D); Ischemic stroke (ISCHSTR); Thrombophilia due to thrombin defect (THPH1); Pregnancy loss, recurrent, 2 (RPRGL2)
Subcellular Location	Secreted, extracellular space
Protein Families	Peptidase S1 family
Tissue Specificity	Expressed by the liver and secreted in plasma.
Paythway	Regulationofactincytoskeleton
Tag Information	N-terminal 6xHis-SUMO-tagged

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