ArtNr |
CSB-EP007111HU-10 |
Hersteller |
Cusabio
|
Menge |
10ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Host |
E.coli |
Purity |
Greater than 90% as determined by SDS-PAGE. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Downstream of tyrosine kinase 5Insulin receptor substrate 6 ;IRS-6 ;IRS6 |
Lieferbar |
|
Research Topic |
Signal Transduction |
Uniprot ID |
Q9P104 |
Gene Names |
DOK5 |
Organism |
Homo sapiens (Human) |
AA Sequence |
MECVGTRINDISLGEPDLLATGVEREQSERFNVYL MPSPNLDVHGECALQITYEYICLWDVQNPRVKLIS WPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQT RDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQM KMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYR LQDVSSPLKLHRTETFPAYRSEH |
Expression Region |
1-198aa |
Sequence Info |
Partial of Isoform 2 |
Source |
E.coli |
Tag Info |
N-terminal 6xHis-SUMO-tagged |
MW |
38.8 kDa |
Alternative Name(s) |
Downstream of tyrosine kinase 5Insulin receptor substrate 6 ; IRS-6 ; IRS6 |
Relevance |
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assbly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. |
Reference |
The full-ORF clone resource of the German cDNA consortium.Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.BMC Genomics 8:399-399(2007) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. |
Protein Families |
DOK family, Type B subfamily |
Tissue Specificity |
Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. |
Tag Information |
N-terminal 6xHis-SUMO-tagged |
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