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Recombinant Human Dopamine beta-hydroxylase(DBH),partial

Recombinant Human Dopamine beta-hydroxylase(DBH),partial

ArtNr	CSB-EP006518HU-10
Hersteller	Cusabio
Menge	10ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	other
Host	E.coli
Purity	Greater than 90% as determined by SDS-PAGE.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Dopamine beta-monooxygenase,Cleaved into the following chain:,Soluble dopamine beta-hydroxylase
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Research Topic	Neuroscience
Uniprot ID	P09172
Gene Names	DBH
Organism	Homo sapiens (Human)
AA Sequence	SAPRESPLPYHIPLDPEGSLELSWNVSYTQEAIHF QLLVRRLKAGVLFGMSDRGELENADLVVLWTDGDT AYFADAWSDQKGQIHLDPQQDYQLLQVQRTPEGLT LLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFRS LEAINGSGLQMGLQRVQLLKPNIPEPELPSDACTM EVQAPNIQIPSQETTYWCYIKELPKGFSRHHIIKY EPIVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCD SKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGLAF GGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYT AKLRRFNAGIMELGLVYTPVMAIPPRETAFILTGY CTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVL VRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHPG DVLITSCTYNTEDRELATVGGFGILEEMCVNYVHY YPQTQLELCKSAVDAGFLQKYFHLINRFNNEDVCT CPQASVSQQFTSVPWNSFNRDVLKALYSFAPISMH CNKSSAVRFQGEWNLQPLPKVISTLEEPTPQCPTS QGRSPAGPTVVSIGGGKG
Expression Region	40-617aa
Sequence Info	Full Length of Mature Protein
Source	E.coli
Tag Info	N-terminal 6xHis-tagged
MW	68.9 kDa
Alternative Name(s)	Dopamine beta-monooxygenase Cleaved into the following chain: Soluble dopamine beta-hydroxylase
Relevance	Conversion of dopamine to noradrenaline.
Reference	"A strategy for precise and large scale identification of core fucosylated glycoproteins."Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.Mol. Cell. Proteomics 8:913-923(2009).
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Conversion of dopamine to noradrenaline.
Involvement in disease	Dopamine beta-hydroxylase deficiency (DBH deficiency)
Subcellular Location	Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen, Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen, Secreted, SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane, Single-pass type II membrane protein, Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane, Single-pass type II membrane protein
Protein Families	Copper type II ascorbate-dependent monooxygenase family
Tag Information	N-terminal 6xHis-tagged

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