ArtNr |
CSB-EP002160RA-1 |
Hersteller |
Cusabio
|
Menge |
1mg |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Konjugat/Tag |
Myc |
Purity |
Greater than 85% as determined by SDS-PAGE. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Lieferbar |
|
Research areas |
Neuroscience |
Target / Protein |
Artn |
Biologically active |
Not Test |
Expression system |
E.coli |
Species of origin |
Rattus norvegicus (Rat) |
Uniprot ID |
Q6AYE8 |
AA Sequence |
AGTRSSRARATDARGCRLRSQLVPVSALGLGHSSD ELIRFRFCSGSCRRARSPHDLSLASLLDAGALRSP PGSRPISQPCCRPTRYEAVSFMDVNSTWRTVDHLS ATACGCLG |
Tag Info |
N-terminal 10xHis-tagged and C-terminal Myc-tagged |
Expression Region |
112-224aa |
Protein length |
Full Length of Mature Protein |
MW |
17.1 kDa |
Relevance |
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue |
References |
"Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex." Baloh R.H., Tansey M.G., Lampe P.A., Fahrner T.J., Enomoto H., Simburger K.S., Leitner M.L., Araki T., Johnson E.M. Jr., Milbrandt J. Neuron 21:1291-1302(1998) |
Purity |
Greater than 85% as determined by SDS-PAGE. |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). |
Subcellular Location |
Secreted |
Protein Families |
TGF-beta family, GDNF subfamily |
Tissue Specificity |
Cochlea. Expressed at higher level in sesorineural epithelium than in the modiolus region or substantia nigra. |
Tag Information |
N-terminal 10xHis-tagged and C-terminal Myc-tagged |
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