ArtNr |
CSB-AP002591HU-10 |
Hersteller |
Cusabio
|
Menge |
10ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Lyophilized powder |
Specific against |
other |
Purity |
>97% as determined by SDS-PAGE and HPLC. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Lieferbar |
|
Classification |
Cytokine |
Subdivision |
Growth Factor |
Research Areas |
Cancer |
Uniprot NO. |
P15692 |
Uniprot Entry Name |
VEGFA_HUMAN |
Gene Names |
VEGFA, VEGF |
Source |
Yeast |
Expression Region |
27-191aa |
Sequence |
M+APMAEGGGQ NHHEVVKFMD VYQRSYCHPI E TLVDIFQEY PDEIEYIFKP SCVPLMRCGG CCN DEGLECV PTEESNITMQ IMRIKPHQGQ HIGEM SFLQH NKCECRPKKD RARQENPCGP CSERRKH LFV QDPQTCKCSC KNTDSRCKAR QLELNERTC R CDKPRR |
Protein Description |
Partial of Isoform VEGF165 |
Tag Info |
Tag-Free |
Mol. Weight |
19.3 kDa |
Biological Activity |
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human umbilical vein endothelial cells(HUVEC) is between 1.0-8.0 ng/ml. |
Purity |
>97% as determined by SDS-PAGE and HPLC. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 um filtered PBS, pH 7.4, with 0.02 % Tween-20 , lyophilized |
Alias |
VEGF-A, VPF |
Relevance |
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. {ECO:0000269|PubMed:11427521, ECO:0000269|PubMed:16489009}. |
PubMed ID |
2479986; 2479987; 1711045; 1791831; 1567395; 9054410; 9878851; 9450968; 10464055; 12124351; 19054851; 14574404; 15489334; 7678805; 15340161; 2584205; 10067980; 11563986; 11427521; 11731620; 11978667; 15520188; 14764596; 15896327; 16489009; 22009797; 9207067; 9336848; 9351807; 9922142; 9634701 |
Function |
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). |
Involvement in disease |
Microvascular complications of diabetes 1 (MVCD1) |
Subcellular Location |
Secreted |
Protein Families |
PDGF/VEGF growth factor family |
Tissue Specificity |
Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland. |
Paythway |
HIF-1signalingpathway |
Tag Information |
Tag-Free |
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