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Recombinant Human C-C motif chemokine 25 protein(CCL25) (Active)

Recombinant Human C-C motif chemokine 25 protein(CCL25) (Active)

ArtNr	CSB-AP000981HU-5
Hersteller	Cusabio
Menge	5ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>97% as determined by SDS-PAGE and HPLC.
ECLASS 5.1	34160400
ECLASS 6.1	34160400
ECLASS 8.0	42020190
ECLASS 9.0	42020190
ECLASS 10.0.1	32160409
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Chemokine TECK, Thymus-expressed chemokine
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Classification	Cytokine
Subdivision	Chemokine
Research Areas	Immunology
Uniprot NO.	O15444
Uniprot Entry Name	CCL25_HUMAN
Gene Names	CCL25, SCYA25, TECK
Source	E.Coli
Expression Region	24-150aa
Sequence	M+QGVFEDCCL AYHYPIGWAV LRRAWTYRIQ E VSGSCNLPA AIFYLPKRHR KVCGNPKSRE VQR AMKLLDA RNKVFAKLHH NTQTFQAGPH AVKKL SSGNS KLSSSKFSNP ISSSKRNVSL LISANSG
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	14.3 kDa
Biological Activity	Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 1.0-10 ng/ml.
Purity	>97% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Alias	Chemokine TECK, Thymus-expressed chemokine
Relevance	Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
PubMed ID	9285413; 14702039; 15057824; 15489334; 10229797; 23341447
Function	Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Subcellular Location	Secreted
Protein Families	Intercrine beta (chemokine CC) family
Tissue Specificity	Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.
Paythway	Chemokinesignalingpathway
Tag Information	Tag-Free

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