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Recombinant Mouse Sonic hedgehog protein(Shh),partial (Active)

Recombinant Mouse Sonic hedgehog protein(Shh),partial (Active)

ArtNr	CSB-AP000521MO-100
Hersteller	Cusabio
Menge	100ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>95% as determined by SDS-PAGE and HPLC.
ECLASS 5.1	34160400
ECLASS 6.1	34160400
ECLASS 8.0	42020190
ECLASS 9.0	42020190
ECLASS 10.0.1	32160409
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	SHH, ,; Sonic hedgehog protein C-product Sonic hedgehog protein 27 kDa product,],
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Classification	Others
Subdivision	Others
Research Areas	Cancer
Uniprot NO.	Q62226
Uniprot Entry Name	SHH_MOUSE
Gene Names	Shh, Hhg1
Source	E.Coli
Expression Region	26-198aa
Sequence	IVIGPGRGFG KRRHPKKLTP LAYKQFIPNV AE KTLGASGR YEGKITRNSE RFKELTPNYN PDII FKDEEN TGADRLMTQR CKDKLNALAI SVMNQW PGVK LRVTEGWDED GHHSEESLHY EGRAVDIT TS DRDRSKYGML ARLAVEAGFD WVYYESKAHI HCSVKAENSV AAKSGG
Protein Description	Partial
Tag Info	Tag-Free
Mol. Weight	19.8 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by inducing alkaline phosphatase production of murine C3H10T1/2 cells is 0.5 - 1.0 ug/ml.
Purity	>95% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered 20 mM PB, pH 7.4, 150mM NaCl , lyophilized
Alias	SHH, , ; Sonic hedgehog protein C-product Sonic hedgehog protein 27 kDa product, ],
Relevance	Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO. {ECO:0000269\|PubMed:14687547, ECO:0000269\|PubMed:7736596}.
PubMed ID	7916661; 7720571; 16141072; 15489334; 7891723; 7736596; 8824192; 11486055; 14687547; 15075292; 16282375; 18081866; 7477329; 18794898; 19561611; 20519495
Function	Sonic hedgehog protein
Subcellular Location	Sonic hedgehog protein N-product: Cell membrane, Lipid-anchor
Protein Families	Hedgehog family
Tissue Specificity	Expressed in a number of embryonic tissues including the notochord, ventral neural tube, floor plate, lung bud, zone of polarizing activity and posterior distal mesenchyme of limbs. In the adult, expressed in lung and neural retina.
Tag Information	Tag-Free

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