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Recombinant Human Somatotropin protein(GH1) (Active)

Recombinant Human Somatotropin protein(GH1) (Active)

ArtNr	CSB-AP000011HU-20
Hersteller	Cusabio
Menge	20ug
Quantity options	1mg 10ug 100ug 20ug 250ug 50ug 500ug
Kategorie	Oncology Peptides & Proteins Recombinant Proteins By Organ Skin Cancer Lymphatic System Cancer
Typ	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>98% as determined by SDS-PAGE and HPLC.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Growth hormone, GH-N, Growth hormone 1, Pituitary growth hormone,
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Classification	Hormone
Subdivision	Hormone
Research Areas	Signal Transduction
Uniprot NO.	P01241
Uniprot Entry Name	SOMA_HUMAN
Gene Names	GH1
Source	E.Coli
Expression Region	27-127aa
Sequence	FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FE EAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNR EETQQK SNLELLRISL LLIQSWLEPV QFLRSV FANS LVYGASDSNV YDLLKDLEEG IQTLMGRL ED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	22.0 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat Nb2-11 lymphoma cells is less than 0.1 ng/ml, corresponding to a specific activity of ? 1.0 x 107 IU/mg.
Purity	>98% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Alias	Growth hormone, GH-N, Growth hormone 1, Pituitary growth hormone,
Relevance	Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
PubMed ID	386281; 377496; 6269091; 7169009; 2744760; 18473352; 16625196; 10931946; 15489334; 3912261; 5810834; 5144027; 4675454; 5279046; 5279528; 7462247; 7356479; 7028740; 8364549; 14997482; 10393484; 16807684; 3447173; 1549776; 7984244; 8943276; 8552145; 9152628; 9276733; 10391209; 11502836; 12655557; 15001589; 15713716; 17519310
Function	Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Involvement in disease	Growth hormone deficiency, isolated, 1A (IGHD1A); Growth hormone deficiency, isolated, 1B (IGHD1B); Kowarski syndrome (KWKS); Growth hormone deficiency, isolated, 2 (IGHD2)
Subcellular Location	Secreted
Protein Families	Somatotropin/prolactin family
Paythway	Jak-STATsignalingpathway
Tag Information	Tag-Free

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