Recombinant Mouse Beta-nerve growth factor(Ngf),partial (Active)

Cytokine

Neuroscience

Ngf

130-239aa

Partial

12.4 kDa

Greater than 95% as determined by SDS-PAGE.

Lyophilized from a 0.2 um Filtered 20 mM Tris-HCl, 200 mM NaCl, pH 8.0

NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an important role in neuroprotection and repair. beta-NGF acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. It is a potent neurotrophic factor that signals through its receptor beta-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.

Secreted

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